Hypolipidemic Activities of a Series of Pyrazoles of Curcumin

A series of curcumin pyrazole derivatives (3a-3e) were investigated for in-vitro hypolipidemic activity. The compounds were screened for the inhibition studies of the enzymes such as pancreatic lipase, glucose 6 phosphate dehydrogenase and malate dehydrogenase which are actively involved in lipid metabolism. Curcumin and all the other compounds in the series showed differential enzyme inhibitory activity. Curcumin and compound 3b showed prominent pancreatic lipase inhibitory activity showing IC50 17.39 and 16 μM respectively. Curcumin, compound 3a and compound 3b exhibited considerable malic dehydrogenase inhibitory activity and the IC50 was found to be 23.42, 18.54 and 22.82 μM respectively. Glucose 6 phosphate dehydrogenase activity was inhibited significantly by curcumin, compounds 3a, 3b and 3e and IC50 was 17.41, 17.11, 14.02 and 18.7 μM respectively. Our results suggest that among the curcumin pyrazole derivatives (3a3e), compound 3a and 3b could be potential hypolipidemic agents and can be promoted for further in-vitro and in vivo investigations.